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Women who carry a mutation in their BRCA 1 or BRCA 2 genes have a 40%-85% chance of developing breast cancer in their lifetime, are more likely to develop breast cancer at a younger age (before menopause), and often have multiple family members with the disease. There is also a lack of evidence about how sensitive preferences might be to the varying estimates of overdiagnosis. 1 Mammography screening involves large numbers of women worldwide, with participants annually numbering over 840 000 in Australia 36 and 2.1 million in the UK. 37 The Australian mammography programme is similar to those in other developed countries: women are invited to a screening service whose leaflets emphasise the benefit without mentioning overdiagnosis (such as www.bsnsw.org.au/publications/early-detection-is-vital ).

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