IBRANCE (Palbociclib): Treatment of Postmenopausal Women

Prior to 1998, although several states had laws requiring health insurance carriers to cover reconstructive surgery, there was no federal legislation and many states did not offer such protection. Ductal carcinoma in situ (DCIS) is the most common form of non-invasive breast cancer (90%). The elevation in risk was most apparent at one year with a HR of 1.81 (1.09 - 3.01); the risks of CHD for years 2 through 6+ were 1.34, 1,27, 1.25, 1,45, and 0.70 In year 6 and beyond, increased rates in the placebo group resulted in an apparent risk reduction�� E+P did not increase or decrease the risks for angina, CABG or PTCA, and congestive heart failure Higher base-line levels of low-density lipoprotein cholesterol were associated with an excess risk of CHD among women who received E+P, but higher base-line levels of C-reactive protein, other biomarkers, and other clinical characteristics did not significantly modify the treatment-related risk of CHD Estrogen plus progestin does not prevent CHD, and may increase the risk of CHD among generally healthy postmenopausal women, especially during the first year after the initiation of hormone use.

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